Skip to main content

Table 1 Univariate analysis for 5-year OS

From: Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

Variable   Patient N° (88) 5-year OS (%) 95% CI p
Age Adult 74 65 53-77 0.003
  AYA 14 100   
Size <5 cm 24 82 66-98 0.4
uk in 4 pts ≥5 cm 60 67 53-80  
Margins° Adequate 68 69 57-81 0.8
  Inadequate 18 76 51-100  
Histology Biphasic 30 67 53-80 0.5
  Other 58 76 59-93  
Chemotherapy No 28 73 67-85 0.5
  Yes 60 68 54-81  
Radiotherapy* No 37 67 51-83 0.07
  Yes 47 77 63-92  
IGF-1R Negative 33 72 53-90 0.3
  Positive 55 69 56-82  
IGF-1R/nuclear Negative 67 73 61-85 0.05
  Positive 21 63 41-85  
CXCR4 Negative 14 92 76-100 0.1
  Positive 74 66 54-78  
CXCR4/nuclear Negative 57 86 76-100 0.0003
  Positive 31 47 54-78  
EZRIN Negative 8 100   0.2
  Positive 80 67 55-78  
EZRIN positivity pattern Cytoplasmatic 49 65 50-79 0.9
  Cyto/membrane 31 70 52-89  
  1. AYA: adolescent and young adults; OS: overall survival; IGF-1R: insulin growth factor-1 receptor; CXCR4: chemokine (C-X-C motif) receptor 4; uk:
  2. °unknown in 2 pts.
  3. *unknown in 4 pts.