Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

Table 1 Univariate analysis for 5-year OS

Variable		Patient N° (88)	5-year OS (%)	95% CI	p
Age	Adult	74	65	53-77	0.003
	AYA	14	100
Size	<5 cm	24	82	66-98	0.4
uk in 4 pts	≥5 cm	60	67	53-80
Margins°	Adequate	68	69	57-81	0.8
	Inadequate	18	76	51-100
Histology	Biphasic	30	67	53-80	0.5
	Other	58	76	59-93
Chemotherapy	No	28	73	67-85	0.5
	Yes	60	68	54-81
Radiotherapy*	No	37	67	51-83	0.07
	Yes	47	77	63-92
IGF-1R	Negative	33	72	53-90	0.3
	Positive	55	69	56-82
IGF-1R/nuclear	Negative	67	73	61-85	0.05
	Positive	21	63	41-85
CXCR4	Negative	14	92	76-100	0.1
	Positive	74	66	54-78
CXCR4/nuclear	Negative	57	86	76-100	0.0003
	Positive	31	47	54-78
EZRIN	Negative	8	100		0.2
	Positive	80	67	55-78
EZRIN positivity pattern	Cytoplasmatic	49	65	50-79	0.9
	Cyto/membrane	31	70	52-89

AYA: adolescent and young adults; OS: overall survival; IGF-1R: insulin growth factor-1 receptor; CXCR4: chemokine (C-X-C motif) receptor 4; uk:
°unknown in 2 pts.
*unknown in 4 pts.

ISSN: 1750-1172