Changes in identified biomarkers are not correlated with severity of the disease. (A-F) For all categories, each dot corresponds to the mean of metabolite content measured in independent red blood cells extracts. AUC values (green numbers) correspond to Area Under Curves values deduced from ROC analyses performed as described in methods. p-values were obtained from a Mann–Whitney–Wilcoxon test: NS: non-statistically different = p-value > 10−1. Control: healthy patients (black circles); HRH: HGprt-related hyperuricemia (orange squares); HND: HGprt-related hyperuricemia with neuromuscular dysfunction (blue squares); LND: full Lesch-Nyhan disease (green squares).