Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension

Table 4 Clinical features and hemodynamic parameters in patients harboring the 3 SNPs of TRPC6 gene and patients with these SNPs plus AGTR1 SNP

Clinical features and hemodynamic parameters	Carriers of c.1-361A > T, c.1-254C > G and c.1-218C > T mutations		Carriers of c.1-361A > T, c.1-254C > G, c.1-218C > T and c.1166A > C mutations
Clinical features and hemodynamic parameters	Clinical data	p-value	Clinical data	p-value
*Number*	19		16
*Gender*	7 F/12 M	0.016	7 F/9 M	0.135
*Age at diagnosis (years)*	51 ± 17	0.348	53 ± 17	0.049
*mPaP (mmHg)*	51 ± 14	0.011	52 ± 16	0.033
*sPaP (mmHg)*	69 ± 20	0.040	68 ± 22	0.222
*PVR (mmHg.l* ⁻¹ .m ⁻¹ )	7.4 ± 2.6	0.576	7.2 ± 2.9	0.533
*CI (l.m* ⁻¹ .m ⁻² )	2.5 ± 0.7	0.000	2.7 ± 0.8	0.002
*6MWT (m)*	363 ± 159	0.049	343 ± 165	0.039

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