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Table 4 Clinical features and hemodynamic parameters in patients harboring the 3 SNPs of TRPC6 gene and patients with these SNPs plus AGTR1 SNP

From: Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension

Clinical features and hemodynamic parameters Carriers of c.1-361A > T, c.1-254C > G and c.1-218C > T mutations Carriers of c.1-361A > T, c.1-254C > G, c.1-218C > T and c.1166A > C mutations
Clinical data p-value Clinical data p-value
Number 19   16  
Gender 7 F/12 M 0.016 7 F/9 M 0.135
Age at diagnosis (years) 51 ± 17 0.348 53 ± 17 0.049
mPaP (mmHg) 51 ± 14 0.011 52 ± 16 0.033
sPaP (mmHg) 69 ± 20 0.040 68 ± 22 0.222
PVR (mmHg.l −1 .m −1 ) 7.4 ± 2.6 0.576 7.2 ± 2.9 0.533
CI (l.m −1 .m −2 ) 2.5 ± 0.7 0.000 2.7 ± 0.8 0.002
6MWT (m) 363 ± 159 0.049 343 ± 165 0.039
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