Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension

Table 2 Clinical features and hemodynamic parameters of patients with each TPRC6 polymorphism

Clinical features and hemodynamic parameters	Carriers of c.1-361A > T mutation		Carriers of c.1-254C > G mutation		Carriers of c.1-218C > T mutation
Clinical features and hemodynamic parameters	Clinical data	p-value	Clinical data	p-value	Clinical data	p-value
*Number*	32		37		32
*Gender*	25 F/7 M	0.002	23 F/14 M	0.177	11 F/21 M	0.035
*Age at diagnosis (years)*	50 ± 16	0.392	48 ± 16	0.403	52 ± 17	0.673
*mPaP (mmHg)*	50 ± 14	0.161	48 ± 14	0.162	48 ± 15	0.307
*sPaP (mmHg)*	71 ± 19	0.190	68 ± 18	0.195	70 ± 20	0.039
*PVR (mmHg.l* ⁻¹ .m ⁻¹ )	7.8 ± 2.3	0.336	7.6 ± 2.6	0.292	8 ± 2.8	0.027
*CI (l.m* ⁻¹ .m ⁻² )	2.6 ± 0.7	0.005	2.6 ± 0.6	0.016	2.6 ± 0.7	0.000
*6MWT (m)*	400 ± 160	0.136	423 ± 152	0.332	395 ± 141	0.168

ISSN: 1750-1172