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Table 5 Gene expression profile of LPS-treated CHS cells compared to LPS-treated control cells

From: Skin fibroblasts from individuals with Chediak-Higashi Syndrome (CHS) exhibit hyposensitive immunogenic response

Gene symbol

Gene full name

Fold regulation

p-value

TLR2

Toll-like receptor 2

−30.20

0.02

IL1A

Interleukin 1, alpha

−7.85

0.01

LTB

Lymphotoxin beta (TNF superfamily, member 3)

−5.80

0.02

IL23A

Interleukin 23, alpha subunit p19

−5.67

0.01

TLR4

Toll-like receptor 4

−4.03

0.01

CCL7

Chemokine (C-C motif) ligand 7

−3.78

0.00

CXCL3

Chemokine (C-X-C motif) ligand 3

−3.66

0.02

CXCR2

Chemokine (C-X-C motif) receptor 2

−3.55

0.02

TLR1

Toll-like receptor 1

−3.31

0.01

IL15

Interleukin 15

−3.23

0.00

CCR1

Chemokine (C-C motif) receptor 1

−2.91

0.03

IL18

Interleukin 18

−2.49

0.00

IL10

Interleukin 10

−2.20

0.05

IL1R1

Interleukin 1 receptor, type I

−2.02

0.01

LY96*

Lymphocyte antigen 96 (MD-2)

2.49

0.01

  1. Note: Table 5 corresponds to the volcano plot of Figure 2A. * LY96, also known as MD-2, was the only gene significantly up-regulated in LPS treated CHS cells.