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Table 5 Gene expression profile of LPS-treated CHS cells compared to LPS-treated control cells

From: Skin fibroblasts from individuals with Chediak-Higashi Syndrome (CHS) exhibit hyposensitive immunogenic response

Gene symbol Gene full name Fold regulation p-value
TLR2 Toll-like receptor 2 −30.20 0.02
IL1A Interleukin 1, alpha −7.85 0.01
LTB Lymphotoxin beta (TNF superfamily, member 3) −5.80 0.02
IL23A Interleukin 23, alpha subunit p19 −5.67 0.01
TLR4 Toll-like receptor 4 −4.03 0.01
CCL7 Chemokine (C-C motif) ligand 7 −3.78 0.00
CXCL3 Chemokine (C-X-C motif) ligand 3 −3.66 0.02
CXCR2 Chemokine (C-X-C motif) receptor 2 −3.55 0.02
TLR1 Toll-like receptor 1 −3.31 0.01
IL15 Interleukin 15 −3.23 0.00
CCR1 Chemokine (C-C motif) receptor 1 −2.91 0.03
IL18 Interleukin 18 −2.49 0.00
IL10 Interleukin 10 −2.20 0.05
IL1R1 Interleukin 1 receptor, type I −2.02 0.01
LY96* Lymphocyte antigen 96 (MD-2) 2.49 0.01
  1. Note: Table 5 corresponds to the volcano plot of Figure 2A. * LY96, also known as MD-2, was the only gene significantly up-regulated in LPS treated CHS cells.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172