Figure 2
From: Oxidative stress and mitochondrial dysfunction in Kindler syndrome
Redox biosensor experiments. (a and b) Retroviruses encoding either Grx1-roGFP2 (a) or mito-Grx1-roGFP2 (b) cDNAs were used to infect KS patients and control keratinocytes. The Ratio 405/488 nm was calculated in basal state and when H2O2 solution was added to the cells (12.5uM). KS patients present higher ratios than controls even at a basal state (without H2O2 solution), indicating a higher oxidized state in both cytoplasmic and mitochondria compartments. Average values of each experimental group are shown. *p < 0.05, **p < 0.01: statistically significant difference from control value, after t-student test.