Figure 2

Activation of Notch signaling. Notch receptors and Jagged/Delta ligands are expressed as single-pass transmembrane proteins. Receptor-ligand interactions lead to the cleavage of the Notch receptor and release of the Notch intracellular domain (NICD) to the cytoplasm. NICD translocates to the nucleus and forms a ternary complex with Rbpjκ and Mastermind-like, displacing transcriptional repressors and associating with transcriptional activators, and inducing expression of Notch target genes.