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Figure 2 | Orphanet Journal of Rare Diseases

Figure 2

From: An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A

Figure 2

Summary of the efficacy analysis, active doses versus Placebo. Least squares mean percentages of relative improvement after 12 months along with 90% CI in all efficacy outcomes after 12 months for LD, ID and HD groups versus Placebo (obtained from Table 3). These estimates and CI were assessed by the ANCOVA efficacy analysis and sorted from highest to lowest value. A negative value of improvement means that the outcome was deteriorated after 12 months. Sample sizes: Placebo (n = 19), LD (n = 21), ID (n = 21), HD (n = 19). The two main efficacy outcomes, CMTNS and ONLS, are indicated with red bold characters. *P < 0.05.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172