Table 1 Search strategy to systematically review treatable IEMs that present as CP mimics
Search strategy | # Treatable CP mimics | ||
|---|---|---|---|
1) PubMed search using combinations of alternative terms to describe the CP phenotype and IEMs | Definition: | Search terms: | 27 |
Cerebral palsy | Cerebral palsy, spastic, spasticity, dystonia, dyskinesia, ataxia, movement disorder, gait abnormalities, hypoxic(+/−ischemic) encephalopathy, perinatal asphyxia | ||
Inborn error of metabolism | Inborn error of metabolism, metabolic disease, amino acids, creatine, mitochondria, neurotransmitter, organic acid, urea cycle, vitamins | ||
2) Manual search | Reference lists of articles identified through PubMed search were manually screened for additional citations. | 15 | |
3) Targeted search of known treatable IEMs causing ID | Diseases listed in the TIDE App (www.treatable-id.org) as treatable IEMs searched in combination with the above IEM search terms. | 12 | |
Total number of IEMs identified | 54 | ||