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Table 1 Minimum inhibitory concentrations and MIC ranges of cystic fibrosis respiratory pathogens versus cysteamine

From: Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

Bacteria (n = 103) Median MIC 100(μg/ml) Range (μg/ml)
P. aeruginosa (n = 42) 250 250-500
P. fluorescens (n = 2) 250-500 250-500
P. putida (n = 1) 250 NA
B. cepacia (n = 3) 250 250-500
B. cenocepacia (n = 3) 500 500-1000
B. multivorans (n = 3) 500 500
Ach. xylosidans (n = 7) 500 250-500
Ach. denitrificans (n = 1) 500 NA
Al. faecalis (n = 2) 250-500 250-500
C. indologenes (n = 2) 250-500  
K. pneumoniae (n = 3) 250 250-1000
Pan. apista (n = 1) 500 NA
Pan. pnomenusa (n = 1) 1000 NA
R. pickettii (n = 3) 500 500-1000
R. mannitolilytica (n = 1) 500 NA
Sph. paucimobilis (n = 2) 1000 1000
St. maltophilia (n = 7) 500 250-1000
S. aureus (n = 14) 250 250-500
  1. Data are median MIC100 of triplicate samples in experiments repeated 3 times. P = Pseudomonas, B = Burkholderia, Ach = Achromobacter, Al = Alcaligenes, C = Chryseomonas, K = Klebsiella, Pan = Pandoraea, R = Ralstonia, Sph = Sphingomonas, St = Stenotrophomonas, S = Staphylococcus, NA = Not applicable.