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Table 1 Minimum inhibitory concentrations and MIC ranges of cystic fibrosis respiratory pathogens versus cysteamine

From: Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

Bacteria (n = 103)

Median MIC 100(μg/ml)

Range (μg/ml)

P. aeruginosa (n = 42)

250

250-500

P. fluorescens (n = 2)

250-500

250-500

P. putida (n = 1)

250

NA

B. cepacia (n = 3)

250

250-500

B. cenocepacia (n = 3)

500

500-1000

B. multivorans (n = 3)

500

500

Ach. xylosidans (n = 7)

500

250-500

Ach. denitrificans (n = 1)

500

NA

Al. faecalis (n = 2)

250-500

250-500

C. indologenes (n = 2)

250-500

 

K. pneumoniae (n = 3)

250

250-1000

Pan. apista (n = 1)

500

NA

Pan. pnomenusa (n = 1)

1000

NA

R. pickettii (n = 3)

500

500-1000

R. mannitolilytica (n = 1)

500

NA

Sph. paucimobilis (n = 2)

1000

1000

St. maltophilia (n = 7)

500

250-1000

S. aureus (n = 14)

250

250-500

  1. Data are median MIC100 of triplicate samples in experiments repeated 3 times. P = Pseudomonas, B = Burkholderia, Ach = Achromobacter, Al = Alcaligenes, C = Chryseomonas, K = Klebsiella, Pan = Pandoraea, R = Ralstonia, Sph = Sphingomonas, St = Stenotrophomonas, S = Staphylococcus, NA = Not applicable.