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Table 1 Clinical profile of patients with DM1

From: Comparisons of intellectual capacities between mild and classic adult-onset phenotypes of myotonic dystrophy type 1 (DM1)

Characteristics Total Classic adult-onset Mild P value
n =188 n =151 n =37
Age, y 45.7 ± 11.0 43.5 ± 9.0 54.9 ± 13.7 <0.001
Sex M:F 72:116 60:91 12:25 n.s.
Education, y 9.9 ± 2.6 9.8 ± 2.5 10.3 ± 2.7 n.s.
Age at onset, ya 21.6 ± 9.4 20.4 ± 7.6 43.7 ± 12.8 <0.001
Disease duration, ya 22.4 ± 8.9 23.0 ± 8.5 10.0 ± 5.4 <0.001
(CTG)n 811.3 ± 524.5 973.3 ± 449.2 149.8 ± 168.0 <0.001
MIRS 3.4 ± 1.1 3.7 ± 0.8 2.3 ± 1.1 <0.001
  1. Mean ± SD.
  2. DM1 = Myotonic Dystrophy type 1; (CTG)n = Cytosine-Thymine-Guanine repeats size;
  3. MIRS = Muscular Impairment Rating Scale.
  4. aData available for 135 DM1 patients; 128 classic adult-onset and 7 mild form.