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Table 1 Clinical profile of patients with DM1

From: Comparisons of intellectual capacities between mild and classic adult-onset phenotypes of myotonic dystrophy type 1 (DM1)

Characteristics

Total

Classic adult-onset

Mild

P value

n =188

n =151

n =37

Age, y

45.7 ± 11.0

43.5 ± 9.0

54.9 ± 13.7

<0.001

Sex M:F

72:116

60:91

12:25

n.s.

Education, y

9.9 ± 2.6

9.8 ± 2.5

10.3 ± 2.7

n.s.

Age at onset, ya

21.6 ± 9.4

20.4 ± 7.6

43.7 ± 12.8

<0.001

Disease duration, ya

22.4 ± 8.9

23.0 ± 8.5

10.0 ± 5.4

<0.001

(CTG)n

811.3 ± 524.5

973.3 ± 449.2

149.8 ± 168.0

<0.001

MIRS

3.4 ± 1.1

3.7 ± 0.8

2.3 ± 1.1

<0.001

  1. Mean ± SD.
  2. DM1 = Myotonic Dystrophy type 1; (CTG)n = Cytosine-Thymine-Guanine repeats size;
  3. MIRS = Muscular Impairment Rating Scale.
  4. aData available for 135 DM1 patients; 128 classic adult-onset and 7 mild form.