|
Characteristics
|
Total
|
Classic adult-onset
|
Mild
|
P value
|
|---|
|
n =188
|
n =151
|
n =37
|
|---|
|
Age, y
|
45.7 ± 11.0
|
43.5 ± 9.0
|
54.9 ± 13.7
|
<0.001
|
|
Sex M:F
|
72:116
|
60:91
|
12:25
|
n.s.
|
|
Education, y
|
9.9 ± 2.6
|
9.8 ± 2.5
|
10.3 ± 2.7
|
n.s.
|
|
Age at onset, ya
|
21.6 ± 9.4
|
20.4 ± 7.6
|
43.7 ± 12.8
|
<0.001
|
|
Disease duration, ya
|
22.4 ± 8.9
|
23.0 ± 8.5
|
10.0 ± 5.4
|
<0.001
|
|
(CTG)n
|
811.3 ± 524.5
|
973.3 ± 449.2
|
149.8 ± 168.0
|
<0.001
|
|
MIRS
|
3.4 ± 1.1
|
3.7 ± 0.8
|
2.3 ± 1.1
|
<0.001
|
- Mean ± SD.
- DM1 = Myotonic Dystrophy type 1; (CTG)n = Cytosine-Thymine-Guanine repeats size;
- MIRS = Muscular Impairment Rating Scale.
- aData available for 135 DM1 patients; 128 classic adult-onset and 7 mild form.
