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Table 2 Specific rare and novel CNVs detected in embryonal carcinoma (Twin-1t) and seminoma (Twin-2t)

From: Genomic screening of testicular germ cell tumors from monozygotic twins

Tumor Sample Cytoband Start (pb) Stop (pb) Size (pb) Event CNV Classification a Genes b
Twin-1 t 16p11.2-p11.1 34.059.589 34.847.384 787796 Gain R NI
Twin-2 t 1p31.1 77.762.182 78.226.565 464384 Gain N NI
  1p22.1 93.075.850 93.586.348 510499 Gain N NI
  2p23.3 27.431.951 27.496.511 64561 Gain N EIF2B4
  2q33.1 201.865.021 202.014.428 149408 Gain N NI
  3q13.13 110.529.591 110.874.657 345067 Loss N NI
  3q13.33 120.713.729 120.813.244 99516 Gain N NI
  6p21.1 42.257.603 42.545.298 287696 Gain N GUCA1A,GUCA1B, MRPS10 and TRERF1
  8p11.23 39.003.502 39.157.973 154472 Loss N ADAM9 and ADAM32
  10q24.1-q24.2 99.386.286 99.516.551 130266 Gain N PI4K2A, AVPI1, MARVELD1, ZFYVE27 and SFRP5
  12q13.3-q14.1 56.296.387 56.308.803 12417 Loss N NI
  12q24.31 119.381.319 119.652.493 271175 Gain N NI
  14q11.2 20.550.697 20.622.417 71721 Loss N NI
  14q23.1 58.887.110 59.149.379 262270 Loss N NI
  15q25.3-q26.1 86.730.625 86.986.408 255784 Gain N MRPL46, MRPS11, DET1, MIR1179, MIR7-2, MIR3529, AEN and ISG20
  17p11.2 19.968.313 20.108.133 139821 Loss N NI
  17p13.1 7.423.749 7.459.204 35456 Gain N NI
  19q13.43 62.712.083 62.882.866 170784 Gain N ZNF773, ZNF549, ZNF550, ZNF416, ZIK1, ZNF530, ZNF134, ZNF211 and ZSCAN4
  20q11.21 29.352.138 29.447.677 95540 Gain N DEFB116, DEFB118 and DEFB119
  Xp22.12-p22.11 20.043.034 21.803.101 1760068 Gain R SCARNA9L, SMPX, YY2 and MBTPS2
  1. Legend: CNV – copy number variation; Twin-1 t – embryonal carcinoma; Twin-2 t – seminoma. Rare – R; Novel – N; No identified – NI. a - CNV classification based on the Database of Genomic Variants and in the Brazilian population reference database. b- Genes mapped in regions described as rare or novel CNV.