Z-score sensory profiles of -10T allele carriers. The Z-score profile of -10T allele carriers shows a predominant loss of sensory function in terms of cold and warm hypoesthesia (CDT, WDT, and TSL) and a reduced mechanical and vibratory sensation (MDT and VDT). The profile is consistent with a selective small fiber neuropathy in FD. Negative Z-scores indicate loss of sensation, positive Z-scores indicate gain of sensation. Error bars represent standard deviation of the mean; n = 10. CDT: cold detection threshold, WDT: warm detection threshold, TSL: thermal sensory limen, CPT: cold pain threshold, HPT: heat pain threshold, PPT: pressure pain threshold, MPT: mechanical pain threshold, MPS: mechanical pain sensitivity, WUR: wind-up ratio, MDT: mechanical detection threshold, VDT: vibration detection threshold.