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Table 2 Analysis of atypical immunoreactive trypsin (≥65 ng/ml) in newborns in a Spanish region

From: Differences in immunoreactive trypsin values between type of feeding and ethnicity in neonatal cystic fibrosis screening: a cross-sectional study

Variable

Total 13310 n(%)/x ± s

AIT 196 (1.5%) n(%)/x ± s

Not AIT 13114 (98.5%) n(%)/x ± s

Adj. OR

95% CI (Adj. OR)

p-value

Gender male

6861(51.5)

95(48.5)

6766(51.6)

0.88

0.66-1.17

0.385

Maternal origin:

      

Spain

9994(75.1)

144(73.5)

9850(75.1)

1

1

0.219

Africa

953(7.2)

22(11.2)

931(7.1)

1.50

0.95-2.37

 

South America

967(7.3)

9(4.6)

958(7.3)

0.63

0.32-1.25

 

Rest of Europe

1061(8.0)

15(7.7)

1046(8.0)

0.88

0.51-1.52

 

Asia

335(2.5)

6(3.1)

329(2.5)

1.21

0.52-2.82

 

Maternal age (years):

      

<20

358(2.7)

8(4.1)

350(2.7)

1.70

0.83-3.49

0.353

20-40

12531(94.1)

182(92.9)

12349(94.2)

1

1

 

>40

421(3.2)

6(3.1)

415(3.2)

1.06

0.46-2.40

 

Gestational age (weeks):

      

<32

146(1.1)

6(3.1)

140(1.1)

1.45

0.49-4.25

0.137

32-37

1568(11.8)

13(6.6)

1555(11.9)

0.59

0.33-1.05

 

>37

11596(87.1)

177(90.3)

11419(87.1)

1

1

 

Feeding method:

      

Natural

8698(65.3)

144(73.5)

8554(65.2)

1

1

<0.001

Mixed

1902(14.3)

16(8.2)

1886(14.4)

0.53

0.31-0.89

 

Formula

2689(20.2)

30(15.3)

2659(20.3)

0.72

0.48-1.07

 

Special

21(0.2)

6(3.1)

15(0.1)

21.88

6.92-69.14

 

Days from extraction >20

47(0.4)

1(0.5)

46(0.4)

1.51

0.21-11.13

0.684

Temperature (°C)

18.7 ± 5.6

18.0 ± 5.2

18.8 ± 5.6

0.98

0.95-1.00

0.064

  1. Abbreviations: AIT atypical immunoreactive trypsin, Adj. OR adjusted odds ratio, CI confidence interval.
  2. Goodness-of-fit of the model: Χ2 = 53.19, p < 0.001.
  3. ORs were adjusted for: gender, maternal origin, maternal age, gestational age, feeding method, days from extraction and temperature.
  4. 2012-2013 data.