Skip to main content

Table 3 Protein expression of selected up regulated genes as detected by immunohistochemistry in tissue sections of SPTL, lupus erythematosus panniculitis (LEP) and erythema nodosum (EN)

From: Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes

Diagnosis Positivity among IDO-1 CXCR3 CXCL9 IL2RB FOXP3
SPTL morphologically malignant cells in adipose tissue 14/19 15/21 15/15 9/14 0/9
++ ++ + + + + + -
  inflammatory infiltrate in dermis 11/19 2/21 4/14 9/14 7/9
++ + + + + or ++
Lupus erythematosus panniculitis (LEP) inflammatory infiltrate 0/5 5/5 6/6 4/6 4/5
- + + + + +
Erythema nodosum (EN) inflammatory infiltrate 0/5 11/12 9/10 8/9 1/5
- + + + + + +
  1. Number of positive cases/all cases studied.
  2. Grading of positive immunostaining: − below 10%, +10-25%, ++ 25-50%, and +++ over 50% of the cells (lymphocytes) expressing the given marker. To note, the positive cells were not always equally distributed in the tissue sections. LEP and EN have no morphologically malignant cells.