Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes

Table 3 Protein expression of selected up regulated genes as detected by immunohistochemistry in tissue sections of SPTL, lupus erythematosus panniculitis (LEP) and erythema nodosum (EN)

Diagnosis	Positivity among	IDO-1	CXCR3	CXCL9	IL2RB	FOXP3
SPTL	morphologically malignant cells in adipose tissue	14/19	15/21	15/15	9/14	0/9
SPTL	morphologically malignant cells in adipose tissue	++	++	+ + +	+ +	-
	inflammatory infiltrate in dermis	11/19	2/21	4/14	9/14	7/9
	inflammatory infiltrate in dermis	++	+	+	+	+ or ++
Lupus erythematosus panniculitis (LEP)	inflammatory infiltrate	0/5	5/5	6/6	4/6	4/5
Lupus erythematosus panniculitis (LEP)	inflammatory infiltrate	-	+	+ +	+	+
Erythema nodosum (EN)	inflammatory infiltrate	0/5	11/12	9/10	8/9	1/5
Erythema nodosum (EN)	inflammatory infiltrate	-	+ + +	+	+	+

Number of positive cases/all cases studied.
Grading of positive immunostaining: − below 10%, +10-25%, ++ 25-50%, and +++ over 50% of the cells (lymphocytes) expressing the given marker. To note, the positive cells were not always equally distributed in the tissue sections. LEP and EN have no morphologically malignant cells.

ISSN: 1750-1172