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Table 4 Dichotomous outcomes in the reviewed studies

From: Quality of life, psychological adjustment, and adaptive functioning of patients with intoxication-type inborn errors of metabolism - a systematic review

Reference N

Instrument

Subscale

n IT-IEM

n control

Results

Test of between group significance

Cramer's V

Psychological adjustment, self-report

     

% present IT-IEM/% present control

Compared to healthy control group

 

Muelly et al., 2013 [24]

SCID, DSM-IV

Depression current

26

26

29/4

χ2 = 22.68; df = 1; p (2-tail) = 0.000 (***)

0.34

N = 26

Depression lifetime

26

26

42/19

χ2 = 12.48; df = 1; p (2-tail) = 0.000 (***)

0.25

  

Anxiety current

26

26

42/15

χ2 = 17.89; df = 1; p (2-tail) = 0.000 (***)

0.30

  

Anxiety lifetime

26

26

58/31

χ2 = 14.96; df = 1; p (2-tail) = 0.000 (***)

0.27

Psychological adjustment, proxy-report

     

n IT-IEM in different categories (n control n.a.)

No group of comparison

 

Gramer et al., 2013 [19]

 

Perceived burden for the child

34

none

No (n = 5), little (n = 17), middle (n = 5), heavy (n = 4), very heavy (n = 3)

n.a.

n.a.

N = 34

      
  

Social behaviour

34

none

Lower than norm (n = 3), same as norm (n = 28), higher than norm (n = 3)

n.a.

n.a.

% normal/at risk/clinically sign. IT-IEM

Compared to population norms

 

(% normal/at risk/clinically sign. control)

Grünert et al., 2013 [26]

SDQ

Emotional symptoms

48

930

62/13/25 (84/7/9)

χ2 = 12.64; df = 2; p (2-tail) = 0.002 (**)

0.25

N = 48

 

Conduct problems

46

930

54/26/20 (69/16/15)

χ2 = 4.93; df = 2; p (2-tail) = 0.085 (ns)

0.15

  

Hyperactivity/Inattention

47

930

62/28/10 (86/6/8)

χ2 = 18.35; df = 2; p (2-tail) = 0.000 (***)

0.30

  

Peer relationship problem

46

930

39/20/41 (78/11/12)

χ2 = 32.92; df = 2; p (2-tail) = 0.000 (***)

0.40

  

Prosocial behaviour

47

930

57/9/34 (89/7/4)

χ2 = 30.95; df = 2; p (2-tail) = 0.000 (***)

0.39

  

Influence on child's life

48

930

60/11/29 (n.a.)

n.a.

n.a.

  

Total

46

930

52/20/28 (85/8/7)

χ2 = 25.69; df = 2; p (2-tail) = 0.000 (***)

0.36

% normal/at risk/clinically sign. IT-IEM

Compared to population norms

 

(% normal/at risk/clinically sign. control)

Krivitzky et al., 2009 [27]

CBCL

Internalising problems

68

576

79/17/4 (83/7/11)

χ2 = 5.87; df = 2; p (2-tail) = 0.053 (ns)

0.17

N = 92

 

Externalising problems

68

576

80/16/4 (83/7/11)

χ2 = 5.26; df = 2; p (2-tail) = 0.072 (ns)

0.16

  1. Abbreviations: CBCL (Child Behaviour Check List), DSM-IV (Diagnostic and Statistical Manual of Mental Disorders IV), SCID (Structured Clinical Interview for DSM-IV), SDQ (Strengths and Difficulties Questionnaire).