Leber’s hereditary optic neuropathy with late disease onset: clinical and molecular characteristics of 20 patients

Table 3 Tobacco and alcohol consumption among late onset-LHON patients, unaffected carriers and "typical" LHON patients

A) Levels of tobacco and alcohol consumption in late onset-LHON patients vs. unaffected carriers over 50 years old
	Affected N =20	Unaffected N =89	p value
	Mean (SD)	Mean (SD)
Cumulative smoking [PY]	23.36 (27.49)	9.25 (13.92)	0.018
Maximum smoking consumption [CPD]	19.33 (17.25)	11.3 (14.56)	0.059
Cumulative alcohol [UY]	137.18 (108.17)	62.23 (87.04)	0.012
Maximum alcohol consumption [UPW]	99.86 (255.71)	14.61 (22.06)	0.000
B) Tobacco and alcohol consumption in late onset- vs. "typical" LHON patients
	Affected N =20 > 50 Years	Affected N =178 < 50 Years
Daily cigarette consumption [CPD]	13.63 (14.48)	10.03 (10.43)	0.619
Weekly alcohol consumption [UPW]	27.78 (29.14)	18.09 (19.47)	0.284

PY = pack years, CPD = cigarettes per day, UY = unit years, UPW = units per week.
3 A) Cumulative and maximum smoking and alcohol consumption in late onset-LHON patients as compared to unaffected carriers over 50 years B) daily cigarette and alcohol consumption before disease onset in late onset- as compared to `typical' LHON patients.

ISSN: 1750-1172