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Table 3 Tobacco and alcohol consumption among late onset-LHON patients, unaffected carriers and "typical" LHON patients

From: Leber’s hereditary optic neuropathy with late disease onset: clinical and molecular characteristics of 20 patients

A) Levels of tobacco and alcohol consumption in late onset-LHON patients vs. unaffected carriers over 50 years old
  Affected N =20 Unaffected N =89 p value
  Mean (SD) Mean (SD)  
Cumulative smoking [PY] 23.36 (27.49) 9.25 (13.92) 0.018
Maximum smoking consumption [CPD] 19.33 (17.25) 11.3 (14.56) 0.059
Cumulative alcohol [UY] 137.18 (108.17) 62.23 (87.04) 0.012
Maximum alcohol consumption [UPW] 99.86 (255.71) 14.61 (22.06) 0.000
B) Tobacco and alcohol consumption in late onset- vs. "typical" LHON patients
  Affected N =20 > 50 Years Affected N =178 < 50 Years  
Daily cigarette consumption [CPD] 13.63 (14.48) 10.03 (10.43) 0.619
Weekly alcohol consumption [UPW] 27.78 (29.14) 18.09 (19.47) 0.284
  1. PY = pack years, CPD = cigarettes per day, UY = unit years, UPW = units per week.
  2. 3 A) Cumulative and maximum smoking and alcohol consumption in late onset-LHON patients as compared to unaffected carriers over 50 years B) daily cigarette and alcohol consumption before disease onset in late onset- as compared to `typical' LHON patients.