Figure 4

Race model test and Miller value spread. A & C). Race model plots depict the Miller value for the neurotypical groups (blue curves) and the Niemann-Pick type C patients (red curves). Values above zero indicate race model violation, which are evident in both the older neurotypicals (N = 16; Panel A) and the younger neurotypicals (N = 19; Panel B), but not in the NPC patients. The shape of the Miller inequality plot observed in the NPC patients is highly atypical and consistent across all three patients. B & D). Box and Whisker plots depict the spread of Miller values for the first 6 RT quantiles for the neurotypical group and the single subject Miller values for each of the NPC adolescents (red circles and red squares). This plot depicts the spread of Miller values for approximately 99% of both neurotypical groups, with the box representing 50% of the data, the whiskers representing the top 25 and bottom 25 percent, and the horizontal bisecting line representing the median Miller value for each neurotypical group at that quantile. It can be seen that all three NPC patients (red shapes) fall outside of the distribution of Miller values for their age-matched neurotypical group. Multisensory facilitation at the individual participant level was noted in all 16 of the 13-15 year olds and in 16 of 19 of the 11-12 year old neurotypicals.