Levels of unprocessed cathelicidin hCAP18 and mature LL-37 in saliva and gingival crevicular fluid. Levels of unprocessed cathelicidin hCAP18 and mature LL-37 in saliva (A) and gingival crevicular fluid (C) obtained from Papillon-Lefèvre patients (PLS), aggressive periodontitis patients (AP), chronic periodontitis patients (CP) and healthy controls (con) determined by western blot analysis. The results present median, and 25th and 75th percentiles. Panel B shows Western blot patterns of LL-37 immunoreactive proteins/peptides in GCF samples collected from PLS patients (#1 - #11) as well as representative samples of chronic periodontitis (CP) and aggressive periodontitis (AP) as well as from healthy controls (con). Arrows point to bands immunoreactive against anti-LL-37 antibody, representing intact hCAP18/LL-37, 11 kDa fragment of hCAP18/LL-37, and the LL-37 peptide.