Table 3 Bone metabolism markers in patient 1–4 in the last denosumab treatment cylce

Parameter/day after denosumab injection

Day 0

Day 0

14

28

Day 0

14

28

Day 0

14

28

Osteocalcin (age adjusted normal range) [ng/ml]

24 (10.0-100.0)

45 (10.0-50.0)

40 (10.0-50.0)

21 (9.6-41.0)

Parathyroid hormone (12–72 ng/l)

16

7

40

31

14

22

19

48

45

46

Calcium (2.2-2.65 mmol/l)

2.48

2.48

2.14

2.35

2.39

2.25

2.35

2.37

2.31

2.46

25-OH Vitamin D (30–70 μg/l)

19

15.4

23.2

26.7

8.2

8.8

4.3

12.2

10.8

8.1

Desoxypyridinoline/creatinine (age adjusted normal range) [μg/g]

600 (110-450)

477 (110-450)

110 (110-450)

197 (110-450

620 (110-450)

133 (110-450)

431* (110-450)

83 (10-50)

50 (10-50)

23 (10-50)