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Table 3 Bone metabolism markers in patient 1–4 in the last denosumab treatment cylce

From: Two years’ experience with denosumab for children with Osteogenesis imperfecta type VI

  Patient 1 Patient 2 Patient 3 Patient 4
Parameter/day after denosumab injection Day 0 Day 0 14 28 Day 0 14 28 Day 0 14 28
Osteocalcin (age adjusted normal range) [ng/ml] 24 (10.0-100.0) 45 (10.0-50.0)    40 (10.0-50.0)    21 (9.6-41.0)   
Parathyroid hormone (12–72 ng/l) 16 7 40 31 14 22 19 48 45 46
Calcium (2.2-2.65 mmol/l) 2.48 2.48 2.14 2.35 2.39 2.25 2.35 2.37 2.31 2.46
25-OH Vitamin D (30–70 μg/l) 19 15.4 23.2 26.7 8.2 8.8 4.3 12.2 10.8 8.1
Desoxypyridinoline/creatinine (age adjusted normal range) [μg/g] 600 (110-450) 477 (110-450) 110 (110-450) 197 (110-450 620 (110-450) 133 (110-450) 431* (110-450) 83 (10-50) 50 (10-50) 23 (10-50)
  1. *→ Urin collected 3 days after elective surgery of right femur due to dislocation of intramedullary rod.