Changes of areal bone mineral density, vertebral morphology and morphometry within the two years of treatment with denosumab in patient 1 and 2. At the top, lumbar spine radiograms of patient 1 and 2 are presented at start and after 2 years of denosumab treatment showing a re-shaping of the vertebrae in both patients. In the middle, changes of lumbar areal bone mineral density at the starting point of the observation and after one and two years of therapy are presented graphically. At the bottom, data of the lumbar and total bone mineral density display an increase in both patients. Additionally, data of the spine score (vertebral compression and deformity) and projected vertebral area of lumbar vertebrae 2–4 demonstrate an improvement in both patients. Abbreviations: BMD L2-L4: areal bone mineral density of the lumbar vertebrae 2–4.