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Table 2 Grading of recommendations depending on their level of evidence

From: Proposed guidelines for the diagnosis and management of methylmalonic and propionic acidemia

Grade of recommendation Criteria
A If level 1 evidence was found (not the case in this study).
B If level 2 evidence was found.
C If level 3 evidence was found (mainly non-analytical studies such as case reports and case series).
D If level 4 evidence was found (mainly expert opinion).