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Table 4 Contingency table and statistical analysis of splenomegaly data

From: Clinical efficacy of Enzyme Replacement Therapy in paediatric Hunter patients, an independent study of 3.5 years

Group

Pre-post

McNemar test p-value

Positive outcomes

Y-Y

Y-N

N-Y

N-N

Proportion

CI (95%)

A

0

1

3

5

0.63

0.67

(0.299, 0.925)

B

2

2

0

2

0.50

0.67

(0.223, 0.957)

C

2

3

0

2

0.25

0.71

(0.290, 0.963)

A + B

2

3

3

7

1.00

0.67

(0.384, 0.882)

A + B + C

4

6

3

9

0.51

0.68

(0.451, 0.861)

  1. The category "Positive Outcomes" includes both YES-NO (Y-N: improvement) and NO-NO (N-N: stabilization) cases. Confidence intervals, calculated by the Clopper and Pearson method and the p-value of McNemar test are reported. Group A: n = 9, group B: n = 6, group C: n = 7.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172