Premanifest HD gene-expansion carriers | Motor manifest HD gene-expansion carriers | Level of significance | |
---|---|---|---|
N = 51 | N = 56 | p-values | |
Gender (m/f) § | 30/21 | 33/23 | p = 0.32 |
Age at examination # (years) | 36 (20–54) | 50 (24–75) | p < 0.001 |
CAG repeat length # | 42 (39–48) | 43 (40–53) | p < 0.38 |
Disease burden score a | 234.0 (108.0–437.0) | ||
UHDRS-motor b (score) # | 2 (0–5) | 21 (6–51) | p < 0.001 |
TFC c (score) # | 13 (11–13) | 10 (4–13) | p < 0.001 |
MMSE (score) # | 29 (26–30) | 28 (24–30) | p < 0.001 |
MoCA (score) # | 28 (25–30) | 25 (19–30) | p < 0.001 |