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Table 1 Clinical characteristics of the two groups of participants

From: A clinical classification acknowledging neuropsychiatric and cognitive impairment in Huntington’s disease

  Premanifest HD gene-expansion carriers Motor manifest HD gene-expansion carriers Level of significance
N = 51 N = 56 p-values
Gender (m/f) § 30/21 33/23 p = 0.32
Age at examination # (years) 36 (20–54) 50 (24–75) p < 0.001
CAG repeat length # 42 (39–48) 43 (40–53) p < 0.38
Disease burden score a 234.0 (108.0–437.0)   
UHDRS-motor b (score) # 2 (0–5) 21 (6–51) p < 0.001
TFC c (score) # 13 (11–13) 10 (4–13) p < 0.001
MMSE (score) # 29 (26–30) 28 (24–30) p < 0.001
MoCA (score) # 28 (25–30) 25 (19–30) p < 0.001
  1. Data are presented as median (range).
  2. p values were calculated by §Chi-square-test or #Mann–Whitney U test.
  3. aDisease burden score = ((CAGn – 35.5)*Age); bUHDRS-motor: Unified Huntington’s Disease Rating Scale-99, range (0–124); cTFC: Total Function Capacity, range (0–13).