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Table 1 Clinical characteristics of the two groups of participants

From: A clinical classification acknowledging neuropsychiatric and cognitive impairment in Huntington’s disease

 

Premanifest HD gene-expansion carriers

Motor manifest HD gene-expansion carriers

Level of significance

N = 51

N = 56

p-values

Gender (m/f) §

30/21

33/23

p = 0.32

Age at examination # (years)

36 (20–54)

50 (24–75)

p < 0.001

CAG repeat length #

42 (39–48)

43 (40–53)

p < 0.38

Disease burden score a

234.0 (108.0–437.0)

  

UHDRS-motor b (score) #

2 (0–5)

21 (6–51)

p < 0.001

TFC c (score) #

13 (11–13)

10 (4–13)

p < 0.001

MMSE (score) #

29 (26–30)

28 (24–30)

p < 0.001

MoCA (score) #

28 (25–30)

25 (19–30)

p < 0.001

  1. Data are presented as median (range).
  2. p values were calculated by §Chi-square-test or #Mann–Whitney U test.
  3. aDisease burden score = ((CAGn – 35.5)*Age); bUHDRS-motor: Unified Huntington’s Disease Rating Scale-99, range (0–124); cTFC: Total Function Capacity, range (0–13).