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Figure 1 | Orphanet Journal of Rare Diseases

Figure 1

From: IgG4- related disease: an orphan disease with many faces

Figure 1

A: IgG4- related disease with involvement of the orbits, ocular nerves and salivary glands. Contrast- enhanced T1 weighed magnetic resonance coronal imaging of the head showing massive thickening of the infraorbital nerve (red arrow). B: Histopathological examination of orbital muscle (upper panel) and parotid gland biopsies (lower panel) reveals dense lymphoplasmacellular infiltration and fibrosis (left pictures, HE staining) with dense infiltration of IgG4- producing plasma cells (right pictures, anti-IgG4, rabbit monoclonal, 1:1000 a.r., Abcam, Cambridge, UK).

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