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Table 2 Reported and estimated work/school absenteeism due to HAE

From: Socioeconomic burden of hereditary angioedema: results from the hereditary angioedema burden of illness study in Europe

Pain severity of the last attack Estimated attacks per year Reported time missed for last attack (days) Reported time missed between attacks in past 6 months (days) Estimated total absenteeism over 12 monthsa(days)
Mean ± SD / median (range) (95% CI) Mean ± SD / median (range) (95% CI) Mean ± SD / median (range) (95% CI) Mean ± SD / median (range) (95% CI)
Overall (n = 67) 33.2 ± 39.6 1.0 ± 1.6 1.9 ± 2.5 19.9 ± 35.0
12.0 (1.0-156.0) 0.25 (0.0-8.0) 1.0 (0.0-11.0) 8.0 (0.0-210.0)
(23.7-42.7) (0.6-1.4) (1.3-2.5) (11.5-28.2)
None/mild (n = 20) 43.7 ± 48.7 0.5 ± 0.9 2.1 ± 2.7 19.3 ± 47.0
24.0 (1.0-156.0) 0.0 (0.0-3.0) 1.1 (0.0-11.0) 5.0 (0.0-210.0)
(32.8-54.6) (0.3-0.7) (0.5-1.7) (8.8-29.8)
Moderate (n = 33) 30.4 ± 37.3 1.0 ± 1.6 1.2 ± 1.6 16.8 ± 29.2
12.0 (1.0-156.0) 0.4 (0.0-8.0) 0.5 (0.0-6.0) 6.3 (0.0-140.0)
(6.3-17.7) (0.75-1.2) (1.0-1.4) (11.8-20.8)
Severe (n = 14) 24.8 ± 28.1 1.8 ± 1.9 3.3 ± 3.4 28.2 ± 28.2
12.0 (5.0-104.0) 1.1 (0.0-7.0) 3.0 (0.0-10.0) 17.3 (0.0-104.0)
(17.3-32.3) (1.3-2.3) (2.4-4.2) (20.7-35.7)
  1. Note: Estimates based on patients who provided absenteeism data (n = 72); 5 outliers identified and removed (estimated attacks per year ≥ 208 or estimated absenteeism ≥ 258 days); thus, final sample size = 67.
  2. aEstimated absenteeism over 12 months calculated as the mean of the estimates computed at the individual-level; given that the absenteeism data are skewed, these estimates differ from those based on the mean time missed as a group.
  3. Confidence Intervals of means reported.