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Table 4 Values of fixed effects and variabilities for the final model with significant covariates

From: Modeling changes in biomarkers in Gaucher disease patients receiving enzyme replacement therapy using a pathophysiological model

Fixed effects Estimates RSE (%) P-value
C0F ( μg/L) 603 9  
  exp(β_ splen) 1.9 24 10−6
  exp(β_ < 15) 0.3 14 < 10−10
C0C (nmol/h.mL) 8140 12  
C0H (g/dL) 11.6 1  
  exp(β_ man) 1.1 40 0.01
  exp(β_ < 15) 0.9 19 10−8
C0P (/mm3) 68400 4  
  exp(β_ splen) 2.7 8 < 10−10
  exp(β_ < 15) 1.4 24 10−6
rF 0.3 13  
  exp(β_ splen) 0.5 29 0.0005
  exp(β_ man) 1.7 32 0.002
rC 0.1 14  
rH 1.2 1  
  exp(β_ splen) 0.9 25 10−5
rP 2.2 4  
  exp(β_ splen) 0.7 19 10−8
k (years−1) 1.4 11  
Variabilities    
  ω_ C0F 63 8  
  ω_C0C 122 7  
  ω_ C0H 12 6  
  ω_C0P 40 6  
  ω_rF 70 10  
  ω_rC 113 10  
  ω_rH 9 9  
  ω_rP 31 9  
  ω_k 97 10  
  σ_F 29 4  
  σ_C 61 4  
  σ_H 7 2  
  σ_P 20 2  
  1. C0 is initial concentration, r amplitude of variation and k the rate of normalization during ERT. F corresponds to ferritin, C to chitotriosidase, H to hemoglobin and P to platelets. The P-value is for the Wald test. exp β represents the effect of the covariates. Splen corresponds to the covariates splenectomy, <15 indicates patients under 15 years of age and man indicates the covariate sex. ω: standard deviation of inter-individual variability, σ: standard deviation of proportional residual error. RSE: relative standard error.