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Figure 2 | Orphanet Journal of Rare Diseases

Figure 2

From: Modeling changes in biomarkers in Gaucher disease patients receiving enzyme replacement therapy using a pathophysiological model

Figure 2

Spaghetti plot of biomarker concentration versus time during ERT for A) ferritin, B) chitotriosidase, C) hemoglobin and D) platelets. Time 0 corresponds to initiation of ERT, vertical gray line. Green lines correspond to non-splenectomized patients and red lines to splenectomized patients. Gray horizontal lines correspond to the limit of usual values: ferritin <250 μg/L, chitotriosidase <100 nmol/mL/h, hemoglobin >12 g/dL, platelet count >150 000/mm3.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172