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Table 2 Overview of two approaches for measuring indirect costs

From: The economic impact of Marfan syndrome: a non-experimental, retrospective, population-based matched cohort study

  Human capital approach (baseline analysis) Friction cost approach (sensitivity analysis)
Perspective • considers patient’s hours of work that are lost (possibly until patient’s retirement age) • considers patient’s hours of work that are lost until employer can replace the patient
Lost production • measured through patient’s lost earnings (valued at 100%) no cap on duration of absence from work • measured through patient’s lost earnings (valued at 80%) absence from work capped at 76 days (friction period)
Premature death • value of lost hours of work (=earnings) that would have accumulated until patient’s retirement age • value of lost hours of work (=earnings) + value of lost hours of work for a full friction period (valued at 100%)