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Table 3 Clinical and biological features at diagnosis

From: Pulmonary alveolar proteinosis in children on La Réunion Island: a new inherited disorder?

 

n/total (%)*

Clinical characteristics

 

Dyspnea and/or tachypnea

34/34 (100)

Cough

9/34 (26)

Low SaO2 (<92%) or low PaO2 (<70 mmHg)

17/34 (50)

Crackles at pulmonary auscultation

15/34 (44)

Digital clubbing

13/34 (38)

Failure to thrive (weight < - 2 SD)

27/34 (79)

Anorexia

22/33 (67)

Vomiting

7/34 (21)

Hepatomegaly

19/34 (56)

Splenomegaly

10/34 (29)

Biological characteristics

 

Anemia (Hb < 11 g/dL)

20/32 (63)

Hyperleukocytosis (≥15 000/mm3)

17/34 (50)

Thrombocytosis (≥450 000/mm3)

17/30 (57)

High IgG level

29/32 (90)

Hypoalbuminemia (<30 g/L)

17/25 (68)

Elevated AST

18/31 (58)

Elevated ALT

10/30 (33)

Elevated GGT

16/25 (64)

Elevated LDH

21/23 (91)

  1. *: For some parameters, data were not available for all patients. : For the 19 others patients, auscultation was reported as normal.