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Table 3 Clinical and biological features at diagnosis

From: Pulmonary alveolar proteinosis in children on La Réunion Island: a new inherited disorder?

  n/total (%)*
Clinical characteristics  
Dyspnea and/or tachypnea 34/34 (100)
Cough 9/34 (26)
Low SaO2 (<92%) or low PaO2 (<70 mmHg) 17/34 (50)
Crackles at pulmonary auscultation 15/34 (44)
Digital clubbing 13/34 (38)
Failure to thrive (weight < - 2 SD) 27/34 (79)
Anorexia 22/33 (67)
Vomiting 7/34 (21)
Hepatomegaly 19/34 (56)
Splenomegaly 10/34 (29)
Biological characteristics  
Anemia (Hb < 11 g/dL) 20/32 (63)
Hyperleukocytosis (≥15 000/mm3) 17/34 (50)
Thrombocytosis (≥450 000/mm3) 17/30 (57)
High IgG level 29/32 (90)
Hypoalbuminemia (<30 g/L) 17/25 (68)
Elevated AST 18/31 (58)
Elevated ALT 10/30 (33)
Elevated GGT 16/25 (64)
Elevated LDH 21/23 (91)
  1. *: For some parameters, data were not available for all patients. : For the 19 others patients, auscultation was reported as normal.