Figure 1

Genealogical trees of familial cases of pulmonary alveolar proteinosis from La Réunion Island. Genealogical trees of the 5 families with several cases of PAP. Familial forms of PAP in La Réunion Island in our study were characterized by the existence of at least one pair of affected siblings per family in addition of one or two cousins for pedigrees 4 and 5. The coexistence of affected and unaffected children among siblings, the fact that both sexes can be affected, the ascertained consanguinity in family 4 and the transversal distribution of the disease are highly suggestive of an autosomic recessive mode of inheritance.