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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome

Figure 3

CLUSTALW sequence alignment between zinc fingers 18 and 19 of ZNF407 with their corresponding linker (TGEKS, highlighted in green), and zinc fingers 2 and 3 of Aart and its linker (TEGKP, highlighted in green). Asterisks denote sequence identity; colons, sequence similarity as defined by scores coming from the substitution matrix; and dots, sequences with any small positive scores. The residues whose side chains chelate the Zn2+ ion in Aart are underlined (C52, C55, H68, H72 for ZNF407, and C80, C83, H96, and H100 for Aart-A); the Serine residue that undergoes the mutation to Tryptophan is in bold. Basic residues are in blue and acidic in red.

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