Skip to main content

Table 4 Effect of causative ryanodine receptor type 1 mutation

From: Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study

Classification of RyR1 mutation Clinical grading scale   Contracture (mN)     Threshold  
   2 vol% halothane 2 mmol l-1caffeine halothane (vol%) Caffeine (mmol l-1)
Causative 51.10 ± 20.67* + 16.77 ± 9.84 + * 10.94 ± 7.24* 0.81 ± 0.44 + * 1.14 ± 0.63 + *
Unknown causality 38.08 ± 17.46* 11.69 ± 8.99* 8.73 ± 6.90* 1.10 ± 0.58* 1.50 ± 0.64*
None detected 37.55 ± 16.90+ 11.43 ± 10.90+ 7.52 ± 10.02* 1.30 ± 0.83+ 2.35 ± 7.70+
  1. Causative ryanodine receptor type 1 (RyR1) mutations yield greater contractures, lower thresholds and higher raw score in the clinical grading scale (CGS). Results of 189 patients are shown as mean ± standard deviation, Mann–Whitney U test was performed and significant differences (p < 0.05.) were marked with asterisk (*) and cross (+). Despite caffeine contractures there were no significant differences between unknown causality vs. none detected. RyR1 polymorphisms (n = 2), double RyR1 mutations (n = 4) and CaV1.1 mutations (n = 1) are not included in this table.