Classification of RyR1 mutation | Clinical grading scale |   Contracture (mN) |  |   Threshold |  |
---|---|---|---|---|---|
 |  | 2 vol% halothane | 2 mmol l-1caffeine | halothane (vol%) | Caffeine (mmol l-1) |
Causative | 51.10 ± 20.67* + | 16.77 ± 9.84 + * | 10.94 ± 7.24* | 0.81 ± 0.44 + * | 1.14 ± 0.63 + * |
Unknown causality | 38.08 ± 17.46* | 11.69 ± 8.99* | 8.73 ± 6.90* | 1.10 ± 0.58* | 1.50 ± 0.64* |
None detected | 37.55 ± 16.90+ | 11.43 ± 10.90+ | 7.52 ± 10.02* | 1.30 ± 0.83+ | 2.35 ± 7.70+ |