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Figure 6 | Orphanet Journal of Rare Diseases

Figure 6

From: Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity?

Figure 6

Western blot analysis on the ventral lumbar spinal cord of animals co-administered with PRE + RSV. (A) Increased sirtuin 1 expression in SOD1G93A spinal motoneurons after PRE + RSV treatment. (B) Evaluation of Sirt1 activity by measuring the acetylation levels of p53 revealed significant deacetylation and thus, increased activity of Sirt1 in SOD1G93A mice treated with PRE + RSV. (C) Enhanced AMPK activation after PRE + RSV treatment, evidenced by an increased pAMPK/AMPK ratio. (D) Increased Ser896 PKC-specific phosphorylation in NMDA-NR1subunits of animals treated with PRE + RSV. Values are mean ± SEM, *p < 0.05 vs. wild type, #p < 0.05 vs. untreated SOD1G93A mice.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172