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Figure 4 | Orphanet Journal of Rare Diseases

Figure 4

From: Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity?

Figure 4

PRE + RSV administration significantly preserves spinal motoneurons from degeneration. Representative images of L4 spinal cord of (A) wild type, (B) SOD1G93A untreated and (C) PRE + RSV SOD1G93A treated mice. Scale bar, 500 μm. (D) L4-L5 spinal cord motoneuron counts revealed significant neuroprotection exerted by PRE + RSV co-administration compared to untreated SOD1G93A but not to RSV-only or PRE-084-only treatments. Dashed line respresent the mean number of motoneurons per section of wild type mice. Values are mean ± SEM. ***p < 0.05 vs. wild type, ### p < 0.05 vs. untreated SOD1G93A mice.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172