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Table 5 Principles for use of antibiotics/antimicrobials in wound treatment

From: Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa

Topical agents • Restrict the use to critically colonized and infected wounds
• Prefer agents which do not have a systemic formulation (e.g. fusidic acid, mupirocin)
• Use for short periods and rotate to avoid resistances and sensitizations
• Consider retapamulin as a second line treatment for resistant Gram positive bacteria
Systemic agents • Administer in multiple infected lesions
• Start early in malnourished and/or non compliant patients and in infants
• Prescribe antibiotics according to the result of culture
  • Prefer narrow spectrum antibiotics