Table 4 Cognitive/psychiatric defects in our cohort of patients
From: CNS involvement in OFD1 syndrome: a clinical, molecular, and neuroimaging study
Cognitive impairment: type | Cases with CNS structural abnormalities % (n°) | Cases without CNS structural abnormalities % (n°) | Total number of cases % (n°) |
|---|---|---|---|
Mild MI/borderline intelligence: | 32.79 (20/61) | 37.5 (3/8) | 33.33 (23/69) |
Moderate/severe MI | 11.47 (7/61) | 0 (0/8) | 10.14 (7/69) |
MI (severity not specified): | 14.75 (9/61) | 12.5 (1/8) | 14.49 (10/69) |
Total | 59.02 (36/61) | 50 (4/8) | 57.97 (40/69) |
Selective cognitive impairment: | 4.92 (3/61) | 50 (4/8) | 10.14 (7/69) |
 i) language disorders | 3.28 (2/61) | 0 (0/8) | 2.9 (2/69) |
 ii) learning difficulties | 1.64 (1/61) | 37.5 (3/8) | 5.8 (4/69) |
 iii) memory problems | 0 (0/61) | 12.5 (1/8) | 1.45 (1/69) |
Total (MI + selective cognitive impairment) | 63.93 (39/61) | 100 (8/8) | 68.12 (47/69) |
 • Clinical assessment | 34.43 (21/61) | 37.5 (3/8) | 34.78 (24/69) |
 • Specific testing | 29.51 (18/61) | 62.5 (5/8) | 33.33 (23/69) |
Psychiatric disorders: type | Â | Â | Â |
ADHD | 1.59 (1/61) | 12.5 (1/8) | 2.9 (2/69) |
Bipolar disorders | 1.59 (1/61) | 0 (0/8) | 1.45 (1/69) |
Total | 3.28 (2/61) | 12.5 (1/8) | 4.35 (3/69) |