Table 3 Neurological disorders in our cohort of patients
From: CNS involvement in OFD1 syndrome: a clinical, molecular, and neuroimaging study
Neurological disorders: type | Patients with CNS structural abnormalities % (n°) | Patients without CNS structural abnormalities % (n°) | Total number of patients % (n°) |
|---|---|---|---|
Motor delay | 24.6 (15/61) | 25 (2/8) | 24.64 (17/69) |
Epilepsy | 14.75 (9/61) | 12.5 (1/8) | 14.49 (10/69) |
Hypotonia | 8.2 (5/61) | 0 (0/8) | 7.25 (5/69) |
Cranial nerve disorders | 8.2 (5/61) | 0 (0/8) | 7.25 (5/69) |
Sensorineural hearing loss | 6.56 (4/61) | 0 (0/8) | 5.8 (4/69) |
Spasticity | 4.92 (3/61) | 0 (0/8) | 4.35 (3/69) |
Motor coordination deficits | 3.28 (2/61) | 12.5 (1/8) | 4.35 (3/69) |
Hemiparesis | 3.28 (2/61) | 0 (0/8) | 2.9 (2/69) |
Nystagmus | 3.28 (2/61) | 0 (0/8) | 2.9 (2/69) |
Total | 55.74 (34/61) | 37.5 (3/8) | 53.62 (37/69) |