Table 2 Classification, designation and distribution of mucin family
Type of mucin | Designation | Site of expression | |
|---|---|---|---|
Membrane-associated | MUC1 | Almost all glandular epithelial surfaces of respiratory, gastrointestinal and female reproductive tracts, middle ear, salivary gland, mammary gland and normal pancreatic intralobular ducts | |
MUC3A | Gastrointestinal tract epithelium | ||
MUC3B | Gastrointestinal tract epithelium | ||
MUC4 | Respiratory tract, salivary glands, stomach, colon, eye, vagina, ectocervix, uterus and prostate | ||
MUC11 | Gastrointestinal, respiratory, reproductive and urinary tracts, liver and thymus | ||
MUC12 | Colon, stomach, pancreas, prostate and uterus | ||
MUC13 | Gastrointestinal and respiratory tracts, middle ear and kidney | ||
MUC15 | Placenta, salivary gland, thyroid gland, trachea, esophagus, kidney and testis | ||
MUC16 | Ocular surface, respiratory and female reproductive tracts and middle ear | ||
MUC17 | Gastrointestinal tract, fetal kidney and conjuctival epithelium | ||
MUC20 | Kidney, placenta, lung, prostate, liver, colon, esophagus, rectum and middle ear | ||
MUC21 | Respiratory tract, thymus, colon and testis | ||
Secreted | Gel-forming | MUC2 | Goblet cells of small intestine and colon |
MUC5AC | Tracheobronchial goblet cells, gastric epithelial cells, conjunctiva and lacrimal glands | ||
MUC5B | Salivary glands, tracheobronchial and esophageal epithelia, pancreatobiliary and endocervical epithelia | ||
MUC6 | Gastric mucosa, duodenal Brunner’s glands, hepatobiliary tract, pancreatic centroacinar cells and duct, basal endometrial and endocervical glands | ||
Non-gel-forming | MUC19 | Salivary glands, submucosal gland of the tracheal tissue, corneal and conjunctival epithelia and lacrimal gland tissue | |
MUC7 | Epithelium of the oral cavity, minor salivary gland, respiratory tract, submucosal glands of the bronchus, conjunctivae and pancreas | ||
MUC8 | Normal Human Nasal epithelial (NHNE) cells and middle ear epithelium | ||
MUC9 | Fallopian tubes (non-ciliated oviductal epithelial cells) | ||