Figure 4From: Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticumRelative expression of components of BMP2-SMADs-RUNX2 signalling including RUNX2, BMP2, BMP4, SMAD1, SMAD4, SMAD5, SMAD8, Osterix, and Alkaline Phosphatase (ALPL). Relative expression is shown in human PXE fibroblasts and control cells. A significant upregulation of all genes except BMP4 and Osterix was observed compared to controls. (n = 8 and 5 for patients and controls respectively). *p < 0.05.Back to article page