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Table 5 Country-specific multiple linear regression models after stepwise reduction

From: Shining a light in the black box of orphan drug pricing

  Belgium R2 = 0.739 n = 51 Constant = 4.734 France R2 = 0.716 n = 59 Constant = 4.911 Netherlands R2 = 0.570 n = 52 Constant = 4.170 Czech republic R2 = 0.706 n = 41 Constant = 4.329 Italy R2 = 0.656 n = 28 Constant = 5.098 United Kingdom R2 = 0.661 n = 66 Constant = 4.652
Variable (x) Unstand. coeff. p-value Unstand. coeff. p-value Unstand. coeff. p-value Unstand. coeff. p-value Unstand. coeff. p-value Unstand. coeff. p-value
MultipleIND    0.504 0.001 0.570 0.010      0.312 0.028
Repurposed −0.573 0.006 −0.548 0.002 −0.557 0.005 −0.656 0.006    −0.325 0.039
altTx −0.478 0.026 −0.584 0.001      −0.988 0.000 −0.397 0.011
Oral −0.637 0.000 −0.328 0.023    −0.678 0.001    −0.392 0.006
Survimp        0.443 0.035     
Chronic 0.464 0.025      0.445 0.044    0.296 0.089
ImprovQoL 0.565 0.021      0.509 0.060     
  1. Explanatory variables are described in Table 2. N denotes the number of observations. Unstand. coeff. = unstandardized coefficients.