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Table 4 Simple linear regression analysis

From: Shining a light in the black box of orphan drug pricing

  Belgium n = 51 France n = 59 Netherlands n = 52 Czech Republic n = 41 Italy n = 28 United Kingdom n = 66
Variable (x) logBeATXcost= p-value logFrATXcost= p-value logNlATXcost= p-value logCzATXcost= p-value logItATXcost= p-value logUkATXcost= p-value
Cosize 4.422-0.214x 0.329 4.449-0.175x 0.360 4.033 + 0.258x 0.176 4.647-0.520x 0.015* 4.534-0.228x 0.477 4.505-0.115x 0.465
ONCO 4.290 + 0.007x 0.973 4.321 + 0.081x 0.677 4.000 + 0.313x 0.107 4.270 + 0.203x 0.361 4.573-0.326x 0.305 4.414 + 0.040x 0.804
YAUTH 4.584-0.042x 0.406 4.664-0.049x 0.220 4.396-0.044x 0.196 4.765-0.060x 0.267 4.519-0.006x 0.942 4.665-0.039x 0.204
AvailUS 3.837 + 0.600x 0.014* 3.829 + 0.661x 0.004* 3.967 + 0.242x 0.234 4.078 + 0.399x 0.104 3.973 + 0.543x 0.328 4.240 + 0.250x 0.189
MultipleIND 4.159 + 0.558x 0.024* 4.142 + 0.645x 0.001* 3.980 + 0.760x 0.001* 4.277 + 0.277x 0.241 4.277 + 0.595x 0.047* 4.292 + 0.455x 0.007*
REPUR 4.473-0.816x 0.001* 4.495-0.684x 0.003* 4.324-0.711x 0.000* 4.502-0.771x 0.006* 4.505-0.793x 0.303 4.558-0.545x 0.003*
QoLimp 4.239 + 0.451x 0.171 4.248 + 0.556x 0.019* 4.066 + 0.535x 0.069 4.313 + 0.427x 0.200 4.313 + 0.628x 0.052 4.368 + 0.348x 0.090*
Survimp 4.242 + 0.321x 0.274 4.344 + 0.069x 0.803 4.048 + 0.592x 0.031* 4.255 + 0.497x 0.057 4.424 + 0.350x 0.394 4.391 + 0.206x 0.303
dbRCT 4.341-0.089x 0.682 4.389-0.068x 0.724 4.265-0.278x 0.146 4.562-0.390x 0.074 4.435-0.085x 0.772 4.440-0.017x 0.915
altTX 5.000-0.883x 0.001* 4.919-0.782x 0.000* 4.471-0.436x 0.059 4.958-0.676x 0.039* 5.098-0.988x 0.000* 4.906-0.669x 0.000*
Ultrarare 4.200 + 0.303x 0.171 4.245 + 0.295x 0.132 4.132 + 0.163x 0.420 4.381 + 0.086x 0.752 4.281 + 0.353x 0.249 4.347 + 0.193x 0.249
Chronic 3.883 + 0.554x 0.021* 3.954 + 0.493x 0.040* 3.963 + 0.228x 0.289 4.310 + 0.073x 0.785 3.947 + 0.620x 0.124 4.114 + 0.414x 0.027*
Weightbased 4.185 + 0.216x 0.315 4.289 + 0.142x 0.458 4.231-0.209x 0.276 4.222 + 0.305x 0.167 4.346 + 0.351x 0.242 4.321 + 0.235x 0.143
Oral 4.563-0.500x 0.018* 4.609-0.449x 0.017* 4.154-0.040x 0.840 4.650-0.540x 0.012* 4.705-0.411x 0.156 4.623-0.400 0.011*
  1. Explanatory variables are described in Table 2. N denotes the number of observations. All p-values marked in bold with an asterisk are significant at a 0.05 threshold level. ATXcost = annual treatment cost.