From: Shining a light in the black box of orphan drug pricing
Belgium n = 51 | France n = 59 | Netherlands n = 52 | Czech Republic n = 41 | Italy n = 28 | United Kingdom n = 66 | |||||||
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Variable (x) | logBeATXcost= | p-value | logFrATXcost= | p-value | logNlATXcost= | p-value | logCzATXcost= | p-value | logItATXcost= | p-value | logUkATXcost= | p-value |
Cosize | 4.422-0.214x | 0.329 | 4.449-0.175x | 0.360 | 4.033 + 0.258x | 0.176 | 4.647-0.520x | 0.015* | 4.534-0.228x | 0.477 | 4.505-0.115x | 0.465 |
ONCO | 4.290 + 0.007x | 0.973 | 4.321 + 0.081x | 0.677 | 4.000 + 0.313x | 0.107 | 4.270 + 0.203x | 0.361 | 4.573-0.326x | 0.305 | 4.414 + 0.040x | 0.804 |
YAUTH | 4.584-0.042x | 0.406 | 4.664-0.049x | 0.220 | 4.396-0.044x | 0.196 | 4.765-0.060x | 0.267 | 4.519-0.006x | 0.942 | 4.665-0.039x | 0.204 |
AvailUS | 3.837 + 0.600x | 0.014* | 3.829 + 0.661x | 0.004* | 3.967 + 0.242x | 0.234 | 4.078 + 0.399x | 0.104 | 3.973 + 0.543x | 0.328 | 4.240 + 0.250x | 0.189 |
MultipleIND | 4.159 + 0.558x | 0.024* | 4.142 + 0.645x | 0.001* | 3.980 + 0.760x | 0.001* | 4.277 + 0.277x | 0.241 | 4.277 + 0.595x | 0.047* | 4.292 + 0.455x | 0.007* |
REPUR | 4.473-0.816x | 0.001* | 4.495-0.684x | 0.003* | 4.324-0.711x | 0.000* | 4.502-0.771x | 0.006* | 4.505-0.793x | 0.303 | 4.558-0.545x | 0.003* |
QoLimp | 4.239 + 0.451x | 0.171 | 4.248 + 0.556x | 0.019* | 4.066 + 0.535x | 0.069 | 4.313 + 0.427x | 0.200 | 4.313 + 0.628x | 0.052 | 4.368 + 0.348x | 0.090* |
Survimp | 4.242 + 0.321x | 0.274 | 4.344 + 0.069x | 0.803 | 4.048 + 0.592x | 0.031* | 4.255 + 0.497x | 0.057 | 4.424 + 0.350x | 0.394 | 4.391 + 0.206x | 0.303 |
dbRCT | 4.341-0.089x | 0.682 | 4.389-0.068x | 0.724 | 4.265-0.278x | 0.146 | 4.562-0.390x | 0.074 | 4.435-0.085x | 0.772 | 4.440-0.017x | 0.915 |
altTX | 5.000-0.883x | 0.001* | 4.919-0.782x | 0.000* | 4.471-0.436x | 0.059 | 4.958-0.676x | 0.039* | 5.098-0.988x | 0.000* | 4.906-0.669x | 0.000* |
Ultrarare | 4.200 + 0.303x | 0.171 | 4.245 + 0.295x | 0.132 | 4.132 + 0.163x | 0.420 | 4.381 + 0.086x | 0.752 | 4.281 + 0.353x | 0.249 | 4.347 + 0.193x | 0.249 |
Chronic | 3.883 + 0.554x | 0.021* | 3.954 + 0.493x | 0.040* | 3.963 + 0.228x | 0.289 | 4.310 + 0.073x | 0.785 | 3.947 + 0.620x | 0.124 | 4.114 + 0.414x | 0.027* |
Weightbased | 4.185 + 0.216x | 0.315 | 4.289 + 0.142x | 0.458 | 4.231-0.209x | 0.276 | 4.222 + 0.305x | 0.167 | 4.346 + 0.351x | 0.242 | 4.321 + 0.235x | 0.143 |
Oral | 4.563-0.500x | 0.018* | 4.609-0.449x | 0.017* | 4.154-0.040x | 0.840 | 4.650-0.540x | 0.012* | 4.705-0.411x | 0.156 | 4.623-0.400 | 0.011* |