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Table 6 Multiple regression analysis on factors associated with HRQoL in patients with TTR mutations

From: THAOS: Gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease

Predictor variable Parameter estimate Standard error t value p value
Intercept 0.99 0.03 30.53 <0.001
Gender (male vs. female) 0.00 0.01 -0.11 0.909
Age at onset (early vs. late) -0.09 0.01 -6.19 <0.001
Disease duration (years) -0.01 0.00 -6.90 <0.001
Upper GI symptoms -0.07 0.01 -4.77 <0.001
Lower GI symptoms -0.13 0.01 -9.28 <0.001
LTx at enrollment 0.06 0.02 3.19 0.002
  1. Health-related quality of life (HRQoL) was assessed with the EQ-5D Index Score. Age of onset <50 years was regarded as early-onset. GI: gastrointestinal; LTx: liver transplant.