Impact of gastrointestinal symptoms on the nutritional status in patients with TTR mutations. For each gastrointestinal symptom, patients with a given symptom were compared with those without the symptom. In the V30M group, each symptom had a significant negative impact on nutritional status, whereas in the non-V30M group, all symptoms but constipation had a significant negative impact. The modified body mass index (mBMI), calculated by multiplying BMI by serum albumin, was used to assess the nutritional status. Extreme mBMI values (<400 or >2500) were excluded and the TTR V122I, I68L and L111M mutations were excluded from the non-V30M group; p < 0.05 was regarded as statistically significant. Data are presented as box and whisker plots showing median (horizontal line), interquartile range (box), mean (circle) and range of measurements (whisker).