GI symptoms in relation to duration of disease in patients with TTR mutations. Prevalence of gastrointestinal (GI) symptoms in patients with a disease duration of <5 years, 5–10 years and >10 years, respectively. A majority of the patients suffered from GI symptoms even at early stages of the disease, whereas the reported prevalence of GI symptoms in the general population usually ranges from 10 to 25%. Unintentional weight loss, early satiety and alternating diarrhea/constipation were the most common symptoms in all disease stages. The symptom prevalence increased significantly with disease duration for all symptoms (p < 0.002, for all), except for early satiety (p = 0.114).