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Table 2 Basal clinical and laboratory features of patients initially treated with D-penicillamine or zinc

From: Zinc monotherapy is effective in Wilson’s disease patients with mild liver disease diagnosed in childhood: a retrospective study

  D-Penicillamine Zinc P values
Patients (N) 27 (21 males) 15 (9 males)  
Median age at diagnosis (months) 75 (range 39–192) 42 (range 12–101) <0.001*
Median ALT at diagnosis (UI/L) 251 (range 23–582) 110 (range 12–502) 0.022*
Median AST at diagnosis (UI/L) 114 (range 27–205) 67 (range 22–168) 0.059 (NS)
Median GGT at diagnosis (UI/L) 72 (range 11–267) 21 (range 13–119) 0.019*
Basal urinary copper (μg/24 h) 150 (range 14–413) 31 (range 4–780) 0.91 (NS)
Median liver copper content (μg/g dry tissue) 780 (range 60–1660) 989 (range 407–1230) 0.423 (NS)
  1. *P values less than 0.05 were considered statistically significant; NS: not significant.