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Figure 2 | Orphanet Journal of Rare Diseases

Figure 2

From: Targeting epidermal lipids for treatment of Mendelian disorders of cornification

Figure 2

Morphological analysis of lesional skin of patient 1 before (day 0), and 3 months after initiation of treatment (day 90). The haematoxylin & eosin (H&E) staining of a skin sample of patient 1 before treatment showed zones of parakeratosis intermingled with areas of orthohyperkeratosis and marked acanthosis. Lymphocytic infiltrates were found in the dermis. Three months after treatment, the skin morphology as evaluated by H&E was comparable to control skin. Similarly, Ki-67 was strongly enhanced and filaggrin showed a disturbed staining pattern before treatment, features that were reverted after application of the S/C ointment. Scale bars: 100 μm.

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