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Table 2 ICEP patient characteristics at diagnosis

From: Idiopathic eosinophilic pneumonia in children: the French experience

Patient

Clinical presentation

Biology

Imagery

Spirometry

Sex

Age at diagnosis (years)

Atopic history

Delay to diagnosis (days)

Respiratory symptoms

Respiratory exam

General symptoms

Initial blood Eo count/mm3

Maximal blood Eo count/mm3

Total IgE kU/L

Lymphocyte phenotype

T-cell clonality

ANA

BALF cellularity (cell/mm3)

BALF Eo %

BALF lymphocytes %

BALF neutrophils %

BALF macrophages %

Histology

CT scan

 

1

F

15.5

No

60

ED, RD, DC, T

DBS

yes

1510

4600

799

normal

No

1/1280

160,000

28

17

2

53

nd

AO, GGO, N, IST, Ad, B, PE

R, O, D

2

F

13.9

No

60

ED, RD, DC

W, DBS

yes

4601

4600

165

normal

No

_

390,000

44

6

4

46

nd

AO, GGO, B, BV, Ad

R, O, D

3

F

6.8

Yes

120

ED, PC

normal

no

1100

1100

>5000

normal

No

1/100

241,000

21

20

5

52

Positive

dGGO, RN

R

4

M

5

Yes

90

DC

W

no

33,580

48,920

150

2,2% CD3+ CD4- CD8- with TCR αβ

nd

_

450,000

20

5

2

73

nd

pGGO, N, Ad

R

5

F

11.2

Yes

37

ED, RD, DC, CP

H, P

yes

80

1300

1040

nd

Positive (TCR γ gene)

nd

112,000

14

16

43

27

nd

dGGO, RN, Ad, PM

nd

  1. Footnote: F: female, M: male, nd: not determined, ED: exertional dyspnea, RD: rest dyspnea, DC: dry cough, T: chest tightness, PC: productive cough, CP: chest pain, DBS: decreased breath sound, W: wheezing, H: hypoxemia ,P: polypnea, Eo: eosinophils, ANA: antinuclear antibodies, BALF: broncho-alveolar lavage fluid, AO: alveolar opacities, GGO: ground-glass opacities, N: nodules, IST: interlobular septal thickening, Ad: adenopathy, B: bronchiectasis, PE: pleural effusions, BV: peri-broncho-vascular thickening, RN: reticulonodular syndrome, N, nodules, PM: pneumomediastinum, d: diffuse, p: patchy, , D: diffusion impairment, R: restriction, O: obstruction, in bold: diagnostic criteria.