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Table 1 ICEP and IAEP inclusion criteria based on adults series 3

From: Idiopathic eosinophilic pneumonia in children: the French experience

Inclusion criteria for ICEP based on adults series3

Inclusion criteria for IAEP based on adults series3

1) respiratory symptoms present> 2 weeks

1) acute onset with febrile respiratory symptoms (< 1 month, and especially < 7 days duration before medical examination)

2) diffuse pulmonary alveolar consolidation with air bronchogram and/or ground-glass opacities at chest imaging, especially with peripheral predominance

2) bilateral diffuse infiltrates on imaging

3) eosinophil count in bronchoalveolar lavage fluid (BALF) > 40% and/or peripheral blood eosinophilia > 1x109cells/L

3) PaO2 in room air < 60 mmHg, or PaO2/FiO2 < 300 mmHg, or oxygen saturation (SpO2) in room air < 90%

4) absence of other known causes of eosinopilic lung disease*

4) lung eosinophilia with > 25% eosinophils in BALF

5) absence of determined cause of acute eosinophilic pneumonia* (including infection or drug exposure) - recent onset of tobacco smoking or exposure to inhaled dusts may be present

  1. Footnote: * We excluded patients with evidence of: 1) exposure to drugs inducing pulmonary eosinophilia, according to the Pneumotox website (http://www.pneumotox.com); 2) ABPA; 3) positive stool parasite test or positive serologic test for Toxocara canis, Trichinella spiralis, Fasciola hepatica, Strongyloides stercoralis, Brugia malayi or Wuchereria bancrofti; 4) vasculitis or malignancy at the time of diagnosis.