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Table 1 Associations between predictor variables and case/control status

From: Assessing the role of multiple pregnancies in the association between tetralogy of Fallot and assisted reproductive techniques: a path-analysis approach

Characteristics   TOF (N=404) Controls (N=4 250) p
   n* %§ n* %§  
Mother Age (years)      
  Mean (SD) 31.7 (5.6) 30.4 (5.2) <0.001
  Median (p25-p75) 31.5 (28 – 36) 30 (27 – 34)  
  <20 3 0.8 59 1.4 <0.001
  20 – 29 146 36.5 1,809 42.8
  30 – 34 126 31.5 1,434 33.9
  35 – 39 91 22.8 722 17.1
  ≥ 40 34 8.5 203 4.8
  Geographic origin      
  France 200 50.4 2,412 57.9 <0.001
  North Africa 72 18.1 433 10.4
  Subsaharan Africa 39 9.8 550 13.2
  Other 86 21.7 770 18.5
  Occupation      
  None 113 30.9 1,083 26.3 0.096
  Professional 84 23.0 997 24.2
  Intermediate 64 17.5 856 20.8
  Administrative/public service 67 18.3 852 20.7
  Other 38 10.4 330 8.0
Father Age (years)      
  Mean (SD) 35.0 (6.6) 33.9 (6.6) 0.006
  Median (p25-p75) 34 (30 – 39) 33 (29 – 38)  
  <20 1 0.3 5 0.1 0.014
  20 – 29 59 19.5 890 25.8
  30 – 34 94 31.1 1,198 34.7
  35 – 39 79 26.2 734 21.3
  ≥ 40 69 22.9 734 21.3
  Geographic origin      
  France 179 49.2 2,325 58.6 <0.001
  North Africa 66 18.1 416 10.5
  Subsaharan Africa 38 10.4 529 13.3
  Other 81 22.3 700 17.6
  Occupation      
  None 24 7.6 281 7.4 0.014
  Professional 110 34.6 1,474 38.6
  Intermediate 44 13.8 566 14.8
  Administrative/public service 28 8.8 479 12.5
  Other 112 35.2 1,020 26.7
Pregnancy Outcome      
  Still-births 18 4.5 7 0.2 <0.001
  Live-births 269 66.6 4,231 99.6
  Pregnancy terminations 117 29.0 12 0.3
Art None 369 93.4 3,959 96.5 0.004
  IO$ only 11 2.8 77 1.9
  IVF£ only 10 2.5 55 1.3
  IVF+ICSI¥ 5 1.3 13 0.3  
  1. *n represents the number of cases or controls without missing data.
  2. §% calculated with the number of cases or controls without missing data as a denominator.
  3. $Inductors of ovulation.
  4. £In vitro fertilization.
  5. ¥IVF with intracytoplasmic sperm injection.